Universal Remote Controls - Suggestions Needed

I have a Harmony one. I think it's called Harmony as that what it contributes to the marriage. Even my wife can control the home theater system now. The 'Help' button is a stroke of genius in guiding her through stuff if it failed to turn something on.

It's really easy to set up initially. Maybe 30 minutes. But plan on spending another half a day tweaking on it to get it the way you want.